JК
Английский язык :: Беликова Елена
Страница: 67 из 68Review of the disease states treated by plasma exchange reveals that mane of the marker solutes ere of f molecular weight larger (generally greater than 100 000 daltons) than albumin, suggesting membrane filtration as physical separation techniques for their removal.
With presently available membranes, selective passage of albumin (near 70 000 daltons) and lower molecular weight solutes with complete retention of larger molecular weight solutes is difficult to achieve. However, such a complete separation may not be desirable since many higher molecular weight solutes are normal components of plasma To apply some selectivity in the separation of the marker solutes with a high return to the normal constituents of plasma and thus no requirement for plasma product infusion, the technique of cryofiltration was applied.
Cryofiltration is the on-line technique of plasma treatment consisting of plasma cooling followed by membrane filtration. By cooling the plasma, cryogel is deposited on the membrane during the Filtration process. The cryogel has been shown to contain concentrated quantities of the marker solutes. Response to therapy in the majority of patients with rheumatoid arthritis has been from good to excellent. In treatments, decreases in marker solutes have been noted coupled with improvement in clinical symptomology.
Membrane technology appears very promising in the separation and treatment of plasma on-line. Chronic treatment therapies appear safe and well tolerated by the patients.
New words
centrifugal technique – центрифужные технологии
plasma exchange – плазмообмен
therapeutic – терапевтический
metabolic – метаболический
multiple – множественный
extracorporeal – экстракорпоральный
56. Artificial oxygen carries
Artificial oxygen (O 2 ) carries aim at improving O 2 delivery Artificial O 2 carries thus may be used as alternative to allogeneic blood transfusions or to improve tissue oxygenation and function of organs with marginal O 2 supply. Artificial O 2 carries can be grouped into modified hemoglobin (Hb) solutions and perfluorocarbon (PFC) emulsions. The native human Hg molecule needs to be modified in order to decrease O 2 affinity and to prevent rapid dissociation of the native tetramer into dimers. The O 2 transport characteristics of modified Hb solutions and PFC emulsions are fundamentally different. The Hb solutions exhibit a sigmoidal O 2 dissociation curve similar to blood. In contrast, the PFC emulsions are characterised by a linear relationship between O 2 partial pressure and O 2 content. Hb solutions thus provide O 2 transport and unloading capacity similar to blood.
With presently available membranes, selective passage of albumin (near 70 000 daltons) and lower molecular weight solutes with complete retention of larger molecular weight solutes is difficult to achieve. However, such a complete separation may not be desirable since many higher molecular weight solutes are normal components of plasma To apply some selectivity in the separation of the marker solutes with a high return to the normal constituents of plasma and thus no requirement for plasma product infusion, the technique of cryofiltration was applied.
Cryofiltration is the on-line technique of plasma treatment consisting of plasma cooling followed by membrane filtration. By cooling the plasma, cryogel is deposited on the membrane during the Filtration process. The cryogel has been shown to contain concentrated quantities of the marker solutes. Response to therapy in the majority of patients with rheumatoid arthritis has been from good to excellent. In treatments, decreases in marker solutes have been noted coupled with improvement in clinical symptomology.
Membrane technology appears very promising in the separation and treatment of plasma on-line. Chronic treatment therapies appear safe and well tolerated by the patients.
New words
centrifugal technique – центрифужные технологии
plasma exchange – плазмообмен
therapeutic – терапевтический
metabolic – метаболический
multiple – множественный
extracorporeal – экстракорпоральный
56. Artificial oxygen carries
Artificial oxygen (O 2 ) carries aim at improving O 2 delivery Artificial O 2 carries thus may be used as alternative to allogeneic blood transfusions or to improve tissue oxygenation and function of organs with marginal O 2 supply. Artificial O 2 carries can be grouped into modified hemoglobin (Hb) solutions and perfluorocarbon (PFC) emulsions. The native human Hg molecule needs to be modified in order to decrease O 2 affinity and to prevent rapid dissociation of the native tetramer into dimers. The O 2 transport characteristics of modified Hb solutions and PFC emulsions are fundamentally different. The Hb solutions exhibit a sigmoidal O 2 dissociation curve similar to blood. In contrast, the PFC emulsions are characterised by a linear relationship between O 2 partial pressure and O 2 content. Hb solutions thus provide O 2 transport and unloading capacity similar to blood.